The Clinical Information cover photo
The Clinical Information
At Theodent, we understand that dental professionals are committed to providing the best care for their patients. They want to use effective, safe products supported by scientific evidence. That's why we're proud to offer our line of toothpastes featuring Rennou™. This powerful and non-toxic active ingredient has been clinically proven to significantly outperform standard fluoride toothpaste in occluding dentin tubules and treating hypersensitivity. In fact, data suggests that it takes 71 times more fluoride to produce the same remineralization effects as Rennou™. We work with many dental clinics around the world that trust in the power of Rennou™, and we have a wealth of scientific research to back up our claims. On this page, we invite dental practices to learn more about the clinical benefits of Rennou™ and to consider incorporating Theodent into their practice.
For an overview of how Rennou™ works, please click here
For a list of peer-reviewed studies on the effects of Rennou™ on the enamel, see below.
We encourage you to try Theodent toothpaste and give us your honest feedback. Many patients prefer not to use fluoride in their dental care routine, and our toothpaste is a great alternative for them. We are committed to constantly improving our products and advancing Rennou™ in the marketplace. With Theodent, you can trust that you are getting a high-quality and effective oral care solution.
Peer-Reviewed Studies on the Effects of Rennou™ on Enamel
Amaechi, B.T., Mathews, S.M. and Mensinkai, P.K., 2015. Effect of theobromine-containing toothpaste on dentin tubule occlusion in situ. Clinical oral investigations, 19(1), pp.109-116.
Amaechi, B.T., Porteous, N., Ramalingam, K., Mensinkai, P.K., Vasquez, R.C., and Nakamoto, T., 2013. Remineralization of artificial enamel lesions by theobromine. Caries Research, 47(5), pp.399-405.
Chandak, S., Madhu, P.P., Chhabra, K.G., Reche, A., Mahure, G., Giri, S. and Chandak, M., Review on Theobromine: An Alternative to Fluorides in Treating Dentinal Hypersensitivity.
Durhan, M.A., Bilsel, S.O., Gokkaya, B., Yildiz, P.K. and Kargul, B., 2021. Caries Preventive Effects of Theobromine Containing Toothpaste on Early Childhood Caries: Preliminary Results. Acta Stomatologica Croatica, 55(1).
Elsherbini, M.S., 2020. Assessment of remineralization potential of Theobromine and Sodium Fluoride gels on Artificial Caries like lesions. Brazilian Dental Science, 23(3), pp.11-p.
Golfeshan, F., Mosaddad, S.A. and Ghaderi, F., 2021. The Effect of Toothpastes Containing Natural Ingredients Such As Theobromine and Caffeine on Enamel Microhardness: An In Vitro Study. Evidence-Based Complementary and Alternative Medicine, 2021.
Green, R., Lanphear, B., Hornung, R., Flora, D., Martinez-Mier, E.A., Neufeld, R., Ayotte, P., Muckle, G. and Till, C., 2019. Association between maternal fluoride exposure during pregnancy and IQ scores in offspring in Canada. JAMA pediatrics, 173(10), pp.940-948.
Gündoğar, Z.U., Keskin, G. and Çinar, Ç., 2019. Comparison of fluoride and the novel anti-caries agent theobromine on initial enamel caries: an in vitro study. Fluoride, 52(3).
Herisa, H.M., Noerdin, A. and Eriwati, Y.K., 2017, August. The effect of theobromine 200 mg/l topical gel exposure duration against surface enamel hardness resistance from 1% citric acid. In Journal of Physics: Conference Series (Vol. 884, No. 1, p. 012009). IOP Publishing.
Hussein, S.I. and El-Haddad, K.E.S., 2018. COMPARISON BETWEEN SOLUTION AND GEL FORMS OF THEOBROMINE AND SODIUM FLUORIDE IN REMINERALIZATION OF THE DEMINERALIZED HUMAN ENAMEL (SEM and EDXA study). Egyptian Dental Journal, 64(3-July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), pp.2371-2380.
Irawan, M.I.P., Noerdin, A. and Eriwati, Y.K., 2017, August. The effect of time in the exposure of theobromine gel to enamel and surface hardness after demineralization with 1% citric acid. In Journal of Physics: Conference Series (Vol. 884, No. 1, p. 012005). IOP Publishing.
Kargul, B., Özcan, M., Peker, S., Nakamoto, T., Simmons, W.B. and Falster, A.U., 2012. Evaluation of human enamel surfaces treated with theobromine: a pilot study. Oral Health and Preventive Dentistry, 10(3), p.275.
Lakshmi, A., Vishnurekha, C. and Baghkomeh, P.N., 2019. Effect of theobromine in antimicrobial activity: An in vitro study. Dental research journal, 16(2), p.76.
Nakamoto, T., Falster, A.U. and Simmons Jr, W.B., 2016. Theobromine: a safe and effective alternative for fluoride in dentifrices. Journal of caffeine research, 6(1), pp.1-9.
Nakamoto, T., Falster, A.U. and Simmons Jr, W.B., 2022. The Contrasting Effects between Caffeine and Theobromine on Crystallization: How the Non-fluoride Dentifrice Was Developed. Oral Health Care: An Important Issue of the Modern Society, p.317.
Shawky, R. and Khattab, N., 2021. Evaluation of the remineralizing effect of theobromine and fluoride using scanning electron microscope. Egyptian Dental Journal, 67(1-January (Orthodontics, Pediatric & Preventive Dentistry)), pp.119-126.
Shimizu, S., Kusakabe, S., Toyama, M., Takagaki, T., Kitada, N., Yamamoto, K., Ikeda, M., Ichimura, Y., Burrow, M.F., Hotta, M. and Nikaido, T., 2023. Bacterial adhesion and antibacterial property of coating materials containing theobromine and S-PRG filler. Dental Materials Journal, pp.2021-307.
Suryana, M., Irawan, B. and Soufyan, A., 2018, August. The effects of toothpastes containing theobromine and hydroxyapatite on enamel microhardness after immersion in carbonated drink. In Journal of Physics: Conference Series(Vol. 1073, No. 3, p. 032010). IOP Publishing.
Syafira, G., Permatasari, R. and Wardani, N., 2012. Theobromine effects on enamel surface microhardness: in vitro. J Dent Indonesia, 19(2), pp.32-6.
Taneja, V., Nekkanti, S., Gupta, K. and Hassija, J., 2019. Remineralization potential of theobromine on artificial carious lesions. Journal of International Society of Preventive & Community Dentistry, 9(6), p.576.
Thomas, N.A., Shetty, P., Thimmaiah, C., Shetty, S.B., Sabu, N. and Kripalani, K.B., 2021. Comparative evaluation of the remineralization potential of Theobromine and Fluoride containing dentifrices using Scanning Electron Microscopy with Energy Dispersive X-Ray Analysis: An in-vitro Study. Journal of International Dental and Medical Research, 14(4), pp.1314-1320.
Wulandari, N.Y., Irawan, B. and Herda, E., 2018, August. Effects of theobromine toothpaste on prevention of enamel discoloration from coffee. In Journal of Physics: Conference Series (Vol. 1073, No. 3, p. 032009). IOP Publishing.
Yuanita, T., Setyabudi, S. and Adjani, Q.S., 2019. The effect of theobromine and NaF 2% exposure to enamel surface hardness after immersing in orange juice beverage. Conservative Dentistry Journal, 9(2), pp.70-73.
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