In head-to-head studies, theobromine outperformed fluoride.
Published, peer-reviewed research shows the active ingredient in Rennou® remineralizing enamel and occluding dentin tubules more effectively than fluoride, at a fraction of the concentration.
Three findings, three studies
20+ peer-reviewed studies, by theme
The same studies currently listed as a flat wall, regrouped by theme, with live links and a downloadable dossier for dental professionals.
Independent researchers whose published work backs it
Prof. Betül Kargül, PhD
An independent researcher in pediatric dentistry whose published studies evaluate theobromine's effect on human enamel surfaces.
Prof. Bennett T. Amaechi, BDS, MSc, PhD
An independent researcher who authored the head-to-head remineralization and dentin-tubule occlusion studies comparing theobromine to fluoride.
The first fluoride-free cavity varnish cleared for U.S. professional use
Rennou® Varnish received FDA 510(k) clearance, indicated for the relief of dentin hypersensitivity through mechanical occlusion of dentinal tubules. Two studies substantiate it.
Dentin tubule occlusion, in vitro SEM (510(k) performance data, K243777 ↗)Bench testing submitted with the clearance: after a single application, 3% Rennou® Varnish occluded dentinal tubules, deposited mineral within them, and penetrated deep into the tubules, as effective as 5% sodium fluoride varnish (Colgate® PreviDent).
Enamel remineralization, publishedParlakyıldız Gökçe A.N., Keleşoğlu E., Sağır K., Kargül B. Remineralization potential of a novel varnish: an in vitro comparative evaluation. Journal of Clinical Pediatric Dentistry, 48(6), 173-180, 2024. doi 10.22514/jocpd.2024.137. Both 1% and 3% Rennou® remineralized enamel comparably to 5% sodium fluoride, with SEM showing similar large crystals and less porosity.
This clearance applies to the professional Rennou® Varnish only, not to Theodent toothpaste.
For dental professionals
Request a professional sample kit, open a wholesale account, or explore Rennou® Varnish, the fluoride-free varnish for chairside use.
Request a professional kitTell us about your practice
A member of our professional team will follow up about samples, wholesale, and Rennou® Varnish.