Fluoride-Free Toothpaste

Every Theodent formula replaces fluoride with Rennou®, our proprietary mix of ingredients. First explored by Dr. Tetsuo Nakamoto's research group at the LSU School of Dentistry, Rennou® works with the calcium and phosphate already present in your saliva to strengthen the enamel surface. It is non-toxic, safe if accidentally swallowed, protected by two U.S. patents, and supported by peer-reviewed research. See how the technology works and the published studies.

Theodent Classic is our everyday fluoride-free toothpaste in spearmint. Theodent 300 is the clinical-strength formula with a concentrated dose of Rennou®, made for hypersensitivity and enamel erosion. Theodent Kids brings the same chemistry in a chocolate chip flavor children actually want to brush with, and with no fluoride there is no worry if a little gets accidentally swallowed. Bundles and 30-tube cases are here too.

Fluoride-free toothpaste FAQs

Does fluoride-free toothpaste actually work?

Published laboratory and clinical studies on theobromine-based formulas have shown enamel remineralization and dentin tubule occlusion. The full bibliography is on our clinical information page.

How is Theodent different from hydroxyapatite toothpaste?

Hydroxyapatite pastes add synthetic mineral to the tooth surface. Rennou® takes a different route: theobromine encourages the minerals already in your saliva to crystallize on the enamel itself. The approach is exclusive to Theodent; no other toothpaste brand uses theobromine.

Which Theodent should I start with?

Start with Classic for daily care, choose 300 for sensitivity or visible enamel wear, and Kids for children of brushing age. Our FAQ page covers ingredients, usage, and subscriptions.